Can Medical Marijuana Protect Against Alzheimer’s Disease?

Medical Marijuana for Alzheimer's Disease

Medical marijuana has a reputation for making its users spacey and forgetful. It’s counter-intuitive, then, that the same substance that leads you to lock your keys in the car or leave your cell phone at Arby’s shows strong promise in the fight to cure the most stubborn and devastating forms of dementia: Alzheimer’s Disease.

But researchers have shown cannabis and its component cannabinoid chemicals have important brain-protecting effects in a variety of human and animal experiments related to dementia.

What is Alzheimer’s Disease?

Alzheimer’s Disease and the incurable, progressive dementia it causes rips families apart. Far more heartbreaking and frightening than watching a loved one’s body disintegrate with age and illness, dementia seems to rob individuals of their personal identity, slowly removing a lifetime of memory and experience until the sufferer can barely speak or move.

Many spend years in a nearly catatonic state, a limbo between death and life that destroys family caretakers’ health, emotional lives and coping abilities, let alone their finances.

Medical Marijuana For Alzheimer’s DiseaseAlzheimer’s Disease causes extreme shrinkage of the cerebral cortex (they grey matter of the brain, where most neural computations go down). The regions of the brain that are responsible for creating cerebral spinal fluid (the ventricles) also increase. However,  of particular interest is the hippocampus, the brain’s memory center, which undergoes a particular dramatic shrinking as Alzheimer’s Disease starts to take hold of the brain. The potential benefit of medical marijuana for Alzheimer’s Disease is ironic given some research that shows regular cannabis use can shrink the hippocampus.

How common is Alzheimer’s?

The growing prevalence of this brain disorder coupled with the demographics of an aging population has researchers scrambling to find a cure for this intractable horror that grips some 5 million Americans — with a new patient diagnosed in the U.S. every 66 seconds. At this rate, the Alzheimer’s Association projects as many as 16 million Americans could be living with Alzheimer’s by 2050.

What causes Alzheimer’s Disease?

The root cause of Alzheimer’s disease is one of the trickiest questions facing neurologists. Researchers understand the mechanism by which the effects of Alzheimer’s damage the brain and cause dementia, but haven’t figured out how the dysfunction happens in the first place. Hypotheses range from aluminum exposure to poor diet. Genetics, particularly the gene APOE4, have proven to be a major factor, but faulty DNA alone far from fully explains the disease. Its cause is likely a combination of genetic and environmental factors that researchers may never fully tease apart.

But neurologists have extensively documented the differences between a healthy brains and ones with Alzheimer’s. Their research targets two central culprits in causing dementia: protein tangles that scramble brain synapses to compromise intracellular communication, and plaque accumulation — gunk buildup that eventually strangles brain neurons to death.

medical marijuana for Alzheimer's Disease can help combat neurofibrillary plaque buildup
1) A Healthy Neuron, 2) A neuron with amyloid plaques (shown in yellow), 3) A dead neuron being digested by microglia cells (shown in red). Photo credit to GEReports

The protein tangles are made of Tau protein, which, in a healthy brain, scientists believe acts as a sort of scaffold for the dense arrangement of neurons that allow us to form memories, throw a softball, appreciate a Rhianna jam, or argue theoretical physics.

Interestingly, Tau protein tangles are also implicated in chronic traumatic brain injury [CTE], or “punch drunk” syndrome seen in NFL players and boxers. See our article, “CBD for CTE: Can Cannabis Protect Against Concussions?

The plaque that forms is called Beta amyloid (Abeta) plaque. This plaque also appears in small amounts in a healthy brain, increasing slightly with age. In Alzheimer’s, however, the normal flow of cerebrospinal fluid doesn’t clean up this waste product, causing it to crowd out and cut off nutrients to healthy neurons.

Can Medical Marijuana Cure Alzheimer’s?

No cure exists for Alzheimer’s, and existing medications do little to halt its progression. Components in pot, however, have shown significant promise, despite the reactionary drug laws in the U.S. and West that still hamstring cannabis research.

Cannabidiol (CBD), a non-psychoactive marijuana component, has been recently proposed as an antioxidant neuroprotective agent in neurodegenerative diseases,” according to a 2006 study in the Journal of Molecular Medicine. “Moreover, it has been shown to rescue (neurons) from toxicity induced by Abeta peptide. However, the molecular mechanism of cannabidiol-induced neuroprotective effect is still unknown.”

In other words, scientists don’t know how CBD works, but it seems to throw a wrench in the works in the chemical process by which plaque kills brain cells.

medical marijuana for Alzheimer's Disease shows great promise in preventing the tangling of Taue proteins
Tau proteins are normally responsible for helping form microtubules (important highways within neurons). In Alzheimer’s Disease, the Tau proteins can become tangled from too much binding with phosphorous, preventing the formation of microtubules and leading to the death of a neuron. Medical marijuana, particularly CBD, shows some promise in that it can help stop Tau from becoming tangled.

Activation of the cannabinoid receptors in the brain — the “locks” into which the “keys” of cannabis chemicals fit to cause a physiological response — can also inhibit the formation of those nasty tangles of Tau protein. Cannabinoid receptor activation seems to prevent the Tau protein from combining with too much phosphorus. “Hyperphosphorylation” (too much phosphorous binding) is what makes Tau protein form the dangerous tangles, so the ability for medical marijuana to prevent this over-binding is a huge ally towards fighting Alzheimer’s Disease.

Read our article about how the endocannabinoid system works and how it interacts with medical marijuana.

A 2017 study out of Australia condensed and analyzed existing cannabis research on Alzheimer’s and concluded that not only CBD, but also the psychoactive cannabinoid in pot, tetrahydrocannabinol (THC), could also be effective in treating Alzheimer’s dementia, referred to as “AD” in the study.

“Importantly, CBD also reverses and prevents the development of cognitive deficits in AD rodent models,” according to the analysis from Frontiers in Pharmacology. “Interestingly, combination therapies of CBD and THC… possibly mediate greater therapeutic benefits than either (chemical) alone. The studies provide ‘proof of principle’ that CBD and possibly CBD-THC combinations are valid candidates for novel AD therapies.”

 

Medical Marijuana For Alzheimer’s Disease References:

 

https://www.nia.nih.gov/health/what-causes-alzheimers-disease

“What Causes Alzheimer’s Disease?”

National Institute on Aging

National Institutes on Health

 

https://www.alz.org/facts/overview.asp

Alzheimer’s Statistics

Alzheimer’s Association

 

https://www.alz.org/alzheimers_disease_what_is_alzheimers.asp

“What is Alzheimer’s?”

Alzheimer’s Association

 

https://www.ncbi.nlm.nih.gov/pubmed/16389547

“The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells.”

Esposito, G et al

Journal of Molecular Medicine

March 2006

 

“In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer’s Disease”

Georgia Watt and Tim Karl

Frontiers in Pharmacology

Feb. 2017

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090074/

“Tau in Alzheimer Disease and Related Tauopathies”
Khalid Iqbal et al

Current Alzheimer’s Research

Dec. 2010

About Nicco Reggente, PhD 95 Articles
Nicco is the co-founder and CEO of WoahStork and Strain Genie-- two companies dedicated to bringing to life his passion of bringing personalized medicine to the cannabis industry. Nicco received his PhD from UCLA in cognitive neuroscience with a focus on machine learning applied to neuroimaging datasets. He previously received two B.As from NYU in Psychology and Philosophy.

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